Ray Romano
Born: December 21, 1957 (age 66 years), Queens, New York, United States
Ray Romano plays, Manny, a mammoth. He is initially portrayed as a gruff and solitary figure, having lost his family to human hunters. Despite his tough exterior, Manny gradually shows a caring side as he forms unlikely friendships with a sloth named Sid and a sabertooth tiger named Diego.
John Leguizamo
Jon Leguizamo Born: July 22, 1960 (age 64 years), Bogotá, Colombia
Sid, a talkative and clumsy sloth. He is a social, albeit somewhat obnoxious, character who tends to get himself into trouble due to his impulsive nature and lack of common sense. Sid is an orphan who is rejected by his own kind, leading him to form an unlikely bond with Manny the mammoth. Despite his faults, Sid has a big heart and a strong desire for companionship.
Denis Leary
Born: August 18, 1957 (age 67 years), Worcester, Massachusetts, United States
Denis Leary plays, Diego, a saber-tooth tiger. Initially introduced as a cunning and dangerous predator, Diego's true intentions are revealed when it becomes clear he has been tasked with leading a group of sabertooths to capture a human baby. However, as he spends more time with Manny, Sid, and the baby, Diego begins to question his mission and his loyalty to his own kind. Over time, he develops a strong bond with the group, particularly with Manny, and proves to be an ally rather than an enemy.
Jack Black
Born: August 28, 1969 (age 55 years), Santa Monica, California, United States
Jack Black plays, Zeke. He is one of the three saber-tooth tigers who initially pursue the human baby, along with his fellow tigers, and serves as a member of the hunting group led by Diego. Zeke is depicted as a brutish and aggressive character who is loyal to his pack, but his role is primarily as a threat to the main characters. He, along with his companions, is determined to capture the baby and stop Manny and the others from succeeding in their mission.
Goran Visnjic
Born: September 9, 1972 (age 52 years), Šibenik, Croatia
Goran Visnjic plays, Soto. He is the leader of a group of saber-tooth tigers, and he orchestrates the plan to capture and kill the human baby. Soto harbors a deep grudge against humans and seeks revenge for the loss of his pack members to human hunters. He manipulates Diego, one of his own tigers, to help carry out the mission. Throughout the film, Soto is depicted as ruthless and cunning, driven by his desire for vengeance. However, as Diego begins to bond with Manny and Sid, Soto's plans begin to unravel, leading to his eventual defeat.
Cedric The Entertainer
Born: April 24, 1964 (age 60 years), Jefferson City, Missouri, United States
Cedric plays, Carl. He is a dim-witted and somewhat goofy member of the group of saber-tooth tigers led by Soto. Carl, along with his companion Frank, is tasked with helping Soto capture the human baby. Though not particularly menacing, Carl serves as a comic foil to the more dangerous tigers in the group. His lack of intelligence and clumsy behavior provide some light-hearted moments, but he is ultimately part of the antagonistic force trying to stop Manny and his friends.